Dantrium® Intravenous

About Malignant Hyperthermia

Malignant hyperthermia (MH) is a rare life-threatening condition that is triggered by exposure to certain drugs used for general anesthesia (specifically all volatile anesthetics), nearly all gas anesthetics, and succinylcholine (a neuromuscular blocking/depolarizing muscle relaxant) in patients who have inherited a gene defect for MH. It may be the cause of sudden, unexpected death in an individual undergoing surgery.

Management of MH crises requires various supportive measures individualized for the patient's condition.

The Malignant Hyperthermia Association of the United States (MHAUS) is a valuable resource for the patient and medical professional for information on malignant hyperthermia - www.mhaus.org

Contact Information for MHAUS
Malignant Hyperthermia Association of the US
1 North Main Street
PO Box 1069
Sherburne, NY 13460
Phone: (607) 674-7901
Fax: (607) 674-7910
info@mhaus.org
www.mhaus.org

MH Emergency Hotline
Toll Free: (800) 644-9737 or (800) MH HYPER (U.S. & Canada)
Dial In: 001-1-209-417-3722 (International)

Important Safety Information

Management of Malignant Hyperthermia (MH) crises requires various supportive measures individualized for the patient's condition. Administration of Dantrium® IV is one component of therapy and should not be considered a substitute for these measures. Even when properly treated, an MH crisis can result in death. Adverse events with Dantrium® IV include loss of grip strength, weakness in the legs, drowsiness, thrombophlebitis, and tissue necrosis/injection site reactions secondary to extravasation. There have been rare reports of pulmonary edema, urticaria and erythema.

View the full Prescribing Information for Dantrium® IV

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